高晗，女，博士，讲师。2016年毕业于中国药科大学，攻读海洋药学专业，获理学学士学位；2021年毕业于西北大学，攻读有机化学专业，主要研究细菌耐药性机制与新型酶抑制剂筛选，获理学硕士学位；2025年毕业于南开大学，攻读药理学专业，主要开展单分子力谱技术解析DNA-蛋白互作、端粒长度调控与抗肿瘤靶点研究，获理学博士学位。2026年加入河北大学药学院。以第一作者在ACS Nano、Bioorganic Chemistry等期刊发表SCI论文4篇。

联系方式：E-mail: gaohanyfz@163.com

研究方向：小分子化合物的抗肿瘤、抗菌活性筛选及作用机理研究

代表性论文：

1.Han Gao; Kangkang Ma; Zhiqiang Cao; Xin Hu; Yuwen Wang; Man Lu; Xuetong Zhao; Junrui Zhou; Yanling Liu; Meijie Wang; Zhigang Zhao; Zhuofei Wang; Junyao Li; Yi Li; Yanding Qin; Xu Bao; Yaqing Jing; Feng Wang; Zhongbo Yu, Absolute Length Distribution of Human Telomeres with Single-Molecule Techniques. ACS Nano 2025, 19 (34), 31258-31271.

2.Han Gao; Yanling Liu; Zhongbo Yu, Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers. Journal of Visualized Experiments, 2024, (210), e67251.

3.Han Gao; Jia-Qi Li; Peng-Wei Kang; Jia-Zhu Chigan; Huan Wang; Lu Liu; Yin-Sui Xu; Le Zhai; Ke-Wu Yang, N-acylhydrazones confer inhibitory efficacy against New Delhi metallo-β-lactamase-1. Bioorganic Chemistry 2021, 114, 105138.

4.Han Gao; Ying Ge; Min-Hao Jiang; Cheng Chen; Le-Yun Sun; Jia-Qi Li; Ke-Wu Yang, Real-time monitoring and inhibition of the activity of carbapenemase in live bacterial cells: application to screening of β-lactamase inhibitors. New Journal of Chemistry 2020, 44 (46), 20334-20340.

5.Jia-Qi Li; Han Gao; Le Zhai; Le-Yun Sun; Cheng Chen; Jia-Zhu Chigan; Huan-Huan Ding; Ke-Wu Yang, Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. Bioorganic & Medicinal Chemistry 2021, 38, 116128.