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张东浩

更新时间:2020-08-22 11:58:23点击次数:1049次

张东浩男,教授。2007年在天津大学获生物化工专业博士学位,2007.6-2008.7在日本先端生命工学研究所(FIBER)做博士后研究员。主持国家自然科学基金面上项目1项,省部级项目4项,河北大学多学科交叉项目1项,河北大学引进人才基金1项。近年来,以第一作者或通讯作者在Bioresource Technology、Food Chemistry、Jounal of Biotechnology、Journal of Agricultural and Food Chemistry、Industrial & Engineering Chemistry Research、Colloids and Surfaces B-Biointerfaces等学术期刊上发表SCI论文近30篇,其中JCR一区论文4篇,二区论文12篇。2014年6月获得保定市科技进步一等奖一项,排名第一。2017年指导的硕士学位论文被评为河北省优秀硕士论文。担任多个SCI期刊的论文审稿评议人并获得由国际知名SCI二区期刊Food Chemistry和Biochemical Engineering Journal颁发的“杰出审稿人奖”。曾担任SCI期刊BioMed Research International(IF2.88)的Lead Guest Editor。是科技部及教育部科研项目评审专家,河北省科技奖励评审专家,河北省高新技术企业评审专家,河北省生物工程学会理事。


主讲课程及研究方向

1. 主讲课程:细胞生物学,生物化学实验,微生物与免疫学实验,研究生专业外语

2. 研究方向:新型酶制剂与载体材料的开发,生物催化,酶在药学中的应用


科研项目

1. 国家自然科学基金面上项目,新型磁性“纳米分子笼”的设计及其强化固定化酶性能研究(21878065),2019.1-2022.12,63万元,主持。

2. 河北大学自然科学多学科交叉研究项目,PEG二缩水甘油醚柔性封装固定化酶对酶性能的增效机制研究(DXK201911),2020.1-2022.12,20万元,主持。

3. 河北省教育厅重点项目,新型“开放笼”微反应器对酶催化性能的增效机制研究,2020.1-2022.12,8万元,主持。

4. 河北省自然科学基金面上项目,新型色素配基磁性载体的构建及其亲和吸附固定化酶的研究(B2015201167),2015.1-2017.12,主持人

5. 河北省自然科学基金青年科学基金项目,磁性微球的表面特性对酶固定化的影响研究(B2011201012),2011.1-2013.12,主持人

6. 教育部留学回国人员科研基金,脂肪酶催化选择性水解/酯化及其酶学特性研究(2010年第38批),2010.5-2012.5,主持人


代表性论文

[1] Mei-Na Yang, Ya-Fang Zhang, Gao-Ying Zhi*, Xiao-Fei Gu, Li Han, Dong-Hao Zhang*, Fabricating cholyglycine-glucose-6-phosphate dehydrogenase conjugates for cholyglycine detection, Biotechnology and Applied Biochemistry, 2020, In press. (SCI四区)

[2] Yi-Ping Cao, Yu-Pei Xia, Xiao-Fei Gu, Li Han, Queting Chen, Gao-Ying Zhi, Dong-Hao Zhang*, PEI-crosslinked lipase on the surface of magnetic microspheres and its characteristics, Colloids and Surfaces B: Biointerfaces, 2020, 189, 110874. (SCI二区)

[3] Yu-Pei Xia, Yi-Fang Dou, Xin-Jiang Pei, Yi-Ping Cao, Gao-Ying Zhi*, Dong-Hao Zhang*, Liandong Hu, An efficient protein immobilization strategy: protein encapsulated in nano molecular cages, Journal of Chemical Technology and Biotechnology, 2019, 94, 2248-2255. (SCI二区)

[4] Yi-Fang Dou, Dong-Hao Zhang*, Hang Liu, Yu-Pei Xia, Gao-Ying Zhi, Polyethyleneimine grafting and Cibacron Blue F3GA modifying poly(methylmethacrylate) magnetic microspheres for protein adsorption, Journal of Chemical Technology and Biotechnology, 2018, 93, 994-1002. (SCI二区)

[5] Dong-Hao Zhang*, Jiang-Yan Zhang, Wen-Cai Che, Yun Wang, A new approach to synthesis of benzyl cinnamate: Optimization by response surface methodology, Food Chemistry, 2016, 206, 44-49. (SCI二区)

[6] Dong-Hao Zhang*, Na Chen, Mei-Na Yang, Yi-Fang Dou, Jie Sun, Ya-Dong Liu, Gao-Ying Zhi, Effects of different spacer arms on Cibacron Blue modification and protein affinity adsorption on magnetic microspheres, Journal of Molecular Catalysis B: Enzymatic, 2016, 133, 136-143. (SCI三区)

[7] Yun Wang, Dong-Hao Zhang*, Jiang-Yan Zhang, Na Chen, Gao-Ying Zhi, High-yield synthesis of bioactive ethyl cinnamate by enzymatic esterification of cinnamic acid, Food Chemistry, 2016, 190, 629-633. (SCI二区)

[8] Yun Wang, Dong-Hao Zhang*, Na Chen, Gao-Ying Zhi, Synthesis of benzyl cinnamate by enzymatic esterification of cinnamic acid, Bioresource Technology, 2015, 198, 256-261. (SCI一区)

[9] Dong-Hao Zhang*, Li-Juan Peng, Yun Wang, Ya-Qiong Li, Lipase immobilization on epoxy-activated poly(vinyl acetate-acrylamide) microspheres, Colloids and Surfaces B: Biointerfaces, 2015, 129, 206-210. (SCI二区)

[10] Dong-Hao Zhang*, Ya-Qiong Li, Li-Juan Peng, Na Chen, Lipase immobilization on magnetic microspheres via spacer arms: effect of steric hindrance on the activity, Biotechnology and Bioprocess Engineering, 2014, 19, 838-843. (SCI四区)

[11] Dong-Hao Zhang*, Chao Li, Ling-Ling Xie, and Li-Xia Yuwen, Enzymatic synthesis of L-ascorbyl laurate in DMSO-acetone mixed solvent, Industrial & Engineering Chemistry Research, 2013, 52, 11875-11879. (SCI二区)

[12] Dong-Hao Zhang*, Chao Li, Gao-Ying Zhi, Kinetic and thermodynamic investigation of enzymatic L-ascorbyl acetate synthesis, Journal of Biotechnology, 2013, 168(4), 416-420. (SCI二区)

[13] Dong-Hao Zhang*, Li-Xia Yuwen, Li-Juan Peng, Parameters affecting the performance of immobilized enzyme, Journal of Chemistry, 2013, Article ID 946248.

[14] Dong-Hao Zhang*, Li-Xia Yuwen, Chao Li, Ya-Qiong Li, Effect of poly(vinyl acetate-acrylamide) microspheres properties and steric hindrance on the immobilization of Candida rugosa lipase, Bioresource Technology, 2012, 124, 233-236. (SCI一区)

[15] Dong-Hao Zhang*, Li-Xia Yuwen, Yu-Lei Xie, Wei Li, Xiao-Bing Li, Improving immobilization of lipase onto magnetic microspheres with moderate hydrophobicity/hydrophilicity, Colloids and Surfaces B: Biointerfaces, 2012, 89, 73-78. (SCI二区)

[16] Dong-Hao Zhang*, Yu-Qin Lv, Gao-Ying Zhi, Li-Xia Yuwen, Kinetic biosynthesis of L-ascorbyl acetate by immobilized Thermomyces lanuginosus lipase (Lipozyme TLIM), Bioprocess and Biosystems Engineering, 2011, 34, 1163-1168. (SCI三区)

[17] Dong-Hao Zhang*, Ya-Fang Zhang, Gao-Ying Zhi, Yu-Lei Xie, Effect of hydrophobic/hydrophilic characteristics of magnetic microspheres on the immobilization of BSA, Colloids and Surfaces B: Biointerfaces, 2011, 82, 302-306. (SCI二区)

[18] Dong-Hao Zhang, Takeshi Fujimoto, Sarika Saxena, Hai-Qing Yu, Daisuke Miyoshi, Naoki Sugimoto, Monomorphic RNA G-quadruplex and polymorphic DNA G-quadruplex structures responding to cellular environmental factors, Biochemistry-US, 2010, 49, 4554-4563. (SCI三区)

[19] Hai-Qing Yu, Dong-Hao Zhang, Xiao-Bo Gu, Daisuke Miyoshi, Naoki Sugimoto. Regulation of telomerase activity by thermodynamic stability of DNA•RNA hybrid, Angew. Chem. Int. Ed., 2008, 47, 9034-9038. (SCI一区)

[20] Dong-Hao Zhang, Shu Bai, Meng-Yuan Ren, Yan Sun, Optimization of lipase-catalyzed enantioselective esterification of (±)-menthol in ionic liquid, Food Chemistry, 2008, 109, 72-80. (SCI二区)

[21] Meng-Yuan Ren, Shu Bai, Dong-Hao Zhang, Yan Sun, pH memory of immobilized lipase for (+/-)-Menthol resolution in ionic liquid, Journal of Agricultural and Food Chemistry, 2008, 56, 2388-2391.

[22] Dong-Hao Zhang, Shu Bai, Yan Sun, Lipase-catalyzed regioselective synthesis of monoester of pyridoxine (Vitamin B6) in acetonitrile, Food Chemistry, 2007, 102, 1012-1019. (SCI二区)

[23] Dong-Hao Zhang, Shu Bai, Yan sun, Optimization of lipase-catalyzed regioselective acylation of pyridoxine(Vitamin B6), Journal of Agricultural and Food Chemistry, 2007, 55, 4526-4531 (SCI一区)

[24] Dong-Hao Zhang, Zheng Guo, Xiao-Yan Dong, Yan Sun, Characterization of lipase in reversed micelles formulated with Cibacron Blue F-3GA modified Span 85, Biotechnology Progress, 2007, 23, 108-115 (SCI三区)

[25] 张东浩,白姝,孙彦,海藻糖对脂肪酶的保护机理及酶失活动力学,生物加工过程,2006,4(1),50-53.


获奖成果

1. 酶法合成肉桂酸酯及其优化,河北省优秀硕士论文指导教师荣誉称号,河北省人民政府学位委员会、河北省教育厅,2017年12月。

2. 磁性微球的表面特性对酶固定化的影响研究,保定市科技进步一等奖,2014年6月,排名第一。

3. 2015年和2017年两次获得由Elsevier出版社颁发的“杰出审稿人奖”。


其他

2011年指导“挑战杯”河北省大学生课外科技作品竞赛一项并获得河北省一等奖。2012年指导大学生科技创新项目(STCP)并在结项中评为优秀。2016年指导了国家级大学生创新创业训练项目并获得结题评审优秀。主持教改课题一项:基于酶法选择性合成药物的药学专业综合实验体系建设,河北大学,2015-2016。


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